TagsTransfersAbout the authorChris BeattieShare the loveHave your say Steven Sessegnon delighted with new Fulham contractby Chris Beattie10 months agoSend to a friendShare the loveSteven Sessegnon has signed a new deal with Fulham.The 18-year-old has agreed a deal which keeps him at Craven Cottage until the summer of 2022, with a Club option to extend by a further 12 months.Having come through the Academy since joining as an Under-9 alongside twin brother Ryan, Steven penned his first professional contract with Fulham last summer.“It feels very good,” Sessegnon told fulhamfc.com. “It’s something I’ve been working towards for the last few months and it feels amazing to get it done and over the line.“You could say the first [pro deal] was very special but this one has shown all the hard work I’ve done personally, not just with this Club but with international success as well. It is rewarding helping contribute to the progression of Fulham.“This can only motivate me to keep working harder. I will carry on doing as I am and keep on heading towards the next one.“Hopefully I can make my league debut very soon, but over time I need to keep working hard and knuckling down and see what happens.“You can’t rush this sort of thing. I’m going to take my chance, whenever it might come.“The Millwall game in the Carabao Cup was a great feeling for me. That was something I’m not used to, but one that will push me on, and spur me on in the future to achieve great things.”
November 24, 2002 Concrete pumpoperator Tim [with cowboy hat] of O’Brian Concrete Pumping is directingthe concrete nozzle with Roma Tre student Anita Maruccia on his righttranslating requests from the Sicilian crew. This pour includes thecomplete wall panels between Unit 6 and 7, between Unit 7 and 8,between Unit 8 and 9, and between Unit 9 and 10. [Photo & text: sa] Sicilian crewmembers Filippo and Rosario Bisconti are supervising the concrete flowinto the new M2 panels. [Photo & text: sa] It’s a tricky jobto vibrate the concrete within the small crevice of these panels.[Photo & text: sa] The Novemberworkshop is getting their first construction experience finishing thetop of the wall panels. [Photo & text: sa] The extra concreteis often used to make pavers. [Photo & text: sa]
Belgian operator Belgacom has re-added German channels ARD (Das Erste) and ZDF to its TV platform after reaching a new agreement with the public broadcasters.Belgacom controversially dropped the channels last year after failing to agree licensing terms with ARD and ZDF.At the time the channels accused Belgacom of not compromising, despite ARD and ZDF making “far-reaching concessions”, with Belgacom apparently asking for a two-year pay freeze for the resupply of the channels.However, reports from last year claimed that Belgacom had offered to pay €500,000 per year-for the channels, but had the sum turned down by the German broadcasters.Financial terms of the new agreement were not disclosed.
Samsung has partnered with Rakuten-owned VOD service, Wuaki, to expand its TV Plus service in Europe and sell new release Ultra HD movies.The deal, which was announced at MIPTV in Cannes, will see Samsung and Wuaki team up to sell 4K, High Dynamic Range, film titles through Samung’s smart TV VOD service TV Plus. Wuaki will help to power the IP-based offering.TV Plus, which launched in Germany in January, will be rolled out to four more European countries – France, Italy, Spain, and the UK – and content will be tailored to customers in each region.“Through TV Plus, Rakuten and Samsung have been able to come together to offer consumers a wide variety of content options from an assortment of different genres and interests,” said Jacinto Roca, chief executive officer of Rakuten Wuaki.“Rakuten is excited to grow our partnership with Samsung as we continue to look for new, innovative ways for users to consume the content they desire.”Samsung Electronics’ vice-president of connective TV services, Heeman Lee, said: “We’re proud to partner with Rakuten Wuaki to expand availability of TV Plus in Europe, offering the fastest way to discover the latest 4K HDR movies and entertainment on Samsung QLED TVs.”
Former Channel 4 content chief Jay Hunt is being linked with a role at Apple.According to sources, she has been in talks over an unspecified role at the tech giant’s London office.Jay HuntThe story first emerged on the On the Airwaves news site.Hunt is known to be well in with Apple original video chiefs Jamie Erlicht and Zach van Amburg, having worked with them on Channel 4 sci-fi anthology Philip K. Dick’s Electric Dreams when they were running Sony Pictures Television.Hunt has been heavily linked with another digital content player, Netflix, but has publicly played down that link.She left Channel 4 last month after seven years as chief creative officer with the UK broadcaster, having brought shows such as The Great British Bake Off and Electric Dreams to the commercially funded public service broadcaster.Numerous execs are lining up to replace her at Channel 4, with interviews believed to be in their final stages. BBC Three controller Damian Kavanagh and Hunt’s deputy, Ralph Lee are both in contention, though sources suggest the later may no longer be in the running.On Friday, former BBC director general Danny Cohen was the latest to rule himself out after reports claimed he was unexpected candidate.Apple, meanwhile, has been building out its content team following the appointments of van Amburg and Erlicht has head of video programming.They have hired a number of execs, including former WGN America chief Matt Cherniss, and are thought to be looking at big ticket dramas, despite Apple seemingly not having aAn Apple spokesperson declined to comment when contacted by DTVE sister title TBI, while Hunt couldn’t be reached for comment this morning.
Sponsor Advertisement The only question to be answered is…how much more is left to go to the downside.I was expecting another leg down in the precious metals sometime between Christmas and New Years…but it began yesterday. Ted Butler had been expecting since the Sunday night open in New York.Gold rose gently in early Far East trading, with the ‘high’ tick…around $1,702 spot…coming shortly after 1:00 p.m. in Hong Kong…and by the Comex open it was back to unchanged from Monday’s close.The first of many engineered price declines began shortly before 10:00 a.m. in New York…which may have been an early London p.m. gold fix. It was sold down in stair-step fashion from there, with the final down-leg coming shortly after the 1:30 p.m. Comex close. That was gold’s low price tick of the day…recorded by Kitco as $1,660.10 spot.From there the gold price recovered somewhat…but that smallish rally only lasted until 4:00 p.m. Eastern…and then it traded sideways into the 5:15 p.m. electronic close.Gold finished the Tuesday session at $1,670.90 spot…down $27.20 for the day. Net volume was a very chunky 195,000 contracts.Of course it was silver that JPMorgan et al were really after…and they certainly did a number on it. The sell-off was much more severe, but the price pattern was the same, so I’ll spare you the play-by-play.Silver’s high tick…around $32.55 spot…came shortly before noon Hong Kong time. The low price tick, like gold’s, came ten minutes after the Comex close…and Kitco reported that as $31.25 spot.The subsequent rally pared the losses by a bit…and silver finished the day at $31.64 spot…down 64 cents on the day. Once again silver had an intraday price move of well over a dollar. Net, volume was pretty decent at around 46,000 contracts…but with a price decline of that magnitude, I was hoping for more.The dollar index started the Tuesday trading session at 79.56…then rallied a hair until shortly after the London open before starting to weaken…with the biggest decline coming between 10:00 a.m. and 11:15 a.m. in New York. The index nadir [79.27] occurred at that point…and the dollar index closed at 79.36…down about 20 basis points from Monday’s close.Only Jon Nadler could find a co-relation between the precious metal price activity and the dollar index on a day like yesterday…as any sane and rational person would see no relationship at all. But if you do see some, I’d love to hear your explanation.The gold stocks held up surprisingly well in the early going, but it was the engineered price decline between 11:20 a.m. and precisely 12 o’clock noon in New York that did the most damage to the shares. But once the low was in at 1:40 p.m….the gold stocks recovered…and the HUI only finished down 1.43%.Not surprisingly, the silver stocks got hit harder…and Nick Laird’s Intraday Silver Sentiment Index closed down 2.10%.(Click on image to enlarge)Considering the bear raid by “da boyz” yesterday, the shares held up remarkably well…and don’t forget about what I [and others] have said about buying “while blood is running in the streets”. That expression fits the circumstance before you, perfectly.The CME’s Daily Delivery Report showed that 154 silver contracts were posted for delivery tomorrow. Jefferies was the short/issuer on all of them…and the Bank of Nova Scotia and JPMorgan were the biggest long/stoppers with 116 and 27 contracts respectively. Even with the year starting to wind down, I’m still expecting a reasonable amount of delivery activity between now and then, as the CME reported that there are 325 gold and 636 silver contracts still left open for the December delivery month…from which you have to subtract the 154 silver contracts mentioned above. The link to yesterday’s Issuers and Stoppers Report is here.There were no reported changes in either GLD or SLV yesterday.Switzerland’s Zürcher Kantonalbank updated their gold and silver ETFs as of December 17th. Their gold ETF showed an increase of 28,964 troy ounces…but their silver ETF showed a decline of 498,112 troy ounces.The U.S. Mint had a smallish sales report yesterday. They sold 7,500 ounces of gold eagles…and that was all.The Comex-approved depositories reported receiving 218,678 troy ounces of silver…and shipped 301,002 ounces out the door on Monday. The link to that activity is here.Well, I received an ‘answer’ from the ombudsman over at Scotiabank on Monday, but it sat unopened in my in-box until yesterday, as I didn’t want what I said in my Tuesday column to be influenced by what was in the reply.I didn’t need to worry, as he weaseled his way out of answering it in almost the same manner as the first time. He could have easily have found the answer to my question, as it would certainly be at hand if he’d been allowed to give it to me.Here are the entire contents of his e-mail…Dear Mr. Steer, I am responding to your attached follow-up e-mail, I wish to begin by assuring you that I am not trying to increase your frustration level but I must say that, as I have stated earlier, I find Scotiabank’s earlier response to you to be perfectly reasonable. In fact, I find it completely logical that any clarification about information in an article published by the Commodity Futures Trading Commission should come directly from the Commodity Futures Trading Commission. Yours truly, Charles Dougall OmbudsmanIn the end, it was another “non-denial denial”. They just chose to get out of it by answering a question that I never asked…and avoided the direct question that I did ask. I don’t think they’re being obtuse…I just think that they don’t want to tell the truth. It’s for this very reason that I suspect Scotiabank/Scotia Mocatta of being the “new non-U.S. bank” that suddenly got outed by the CFTC in the November Bank Participation Report. Scotiabank could have ended it all by just telling me…no, it wasn’t them. But they didn’t say that…and I’m suspecting that the reason is because they didn’t want to get caught in a lie later. I guess that’s the lesser of two evils than being caught telling the truth at this point in the game.If you didn’t read it, or don’t remember the question I presented to the ombudsman, the link to yesterday’s GSD column is here.The Queen and The GoldI stole this photo from Eric King’s website…and it’s posted in one of his blogs with James Turk further down in this column. I’m still thunderstruck that Her Majesty [and Prince Philip] were trotted out. There is obviously big trouble in River City that we just aren’t privy to.Here are a couple of charts that Nick Laird sent my way yesterday…and both are show-stoppers. The first shows how many ounces of gold can be bought for $1,000 going back to 1718.(Click on image to enlarge)This second chart shows the lost purchasing power of the U.S. dollar in percentage terms over the same 300-year period. One chart is actually a ‘derivative’ of the other.(Click on image to enlarge)They don’t teach this stuff in school…and as you’re probably already beginning to suspect, there’s a good reason for that. They don’t want the sheeple to know how badly their being fleeced…and by whom…and why.Here’s a cute photo that my sister sent me yesterday…and you though squirrels on your roof were a problem.I have a more reasonable number of news items for you today…and I hope you can find time to wade through them the ones that interest you during the busy holiday season that we all face.It is one thing for an exchange to rush to the aid of important members when an outsider may be doing something wrong and against the insider members’ interests; but it’s a very different story if there was no outside wrongdoing and the insiders were the guilty party. That’s exactly what happened in 2011 on separate occasions…and is still happening to this day in COMEX silver. It is a circumstance without precedent, namely, an exchange working against the public’s interest when there is nothing that the public is doing that is wrong. The thought that the New York Stock Exchange would diligently work to lower overall stock prices is too absurd to contemplate, as it would be shooting itself in the foot. But that’s exactly what the COMEX is doing in silver. The exchange should care less about price levels, but because the most important member of the COMEX (JPMorgan) is up to its eyeballs on the short side, that forces the exchange to be an active partner in attempting to bring about lower silver prices. This is so bad, it is almost inconceivable. Yet the evidence is right in front of us. – Silver analyst Ted Butler…15 December 2012Well, yesterday’s price action in New York should leave no doubt in anyone’s mind that JPMorgan Chase and the rest of their Merry Men showed up in New York yesterday. Using my Ovaltine secret decoder ring…and holding the Kitco chart up at a 33 degree angle in polarized light, it was easy to spot the secret message inscribed in the silver chart. It said “Season’s Greetings to all. Up yours. Jamie…et al“The only question to be answered is…how much more is left to go to the downside. The gold price took out its 200-day moving average by a whisker yesterday…but did not close below it. Silver still has a ways to go yet. But can they, or will they do more to the downside? I don’t know for sure, but suspect that the answer is yes.If they are clearing the decks for a major price rise in the New Year to correspond with the Fed’s attempt to raise the velocity of money by increasing the inflation rate…by a U.S. dollar devaluation, or other means…sending a message to the markets by running up the precious metal prices by a very noticeable amount would be one of the tools they would certainly contemplate using.In order to do that, I’m sure that “da boyz” would like to cover as many short positions as they can in the interim…and that means further price pain to the downside until they get the last possible speculative long position holders to sell. Once they get to that point…whatever prices that takes…no further price reduction is possible, as it’s the very act of technical fund selling [or buying] that ultimately drives the spot price.Here are the 1-year charts for both gold and silver. It’s hard to tell how much more damage they can do to the downside as far as price is concerned, but Ted Butler says it could be considerable…especially in silver.(Click on image to enlarge)(Click on image to enlarge)In the meantime, the CME Group and the CFTC will continue to protect the largest Commercial short holders in all four precious metals…and CFTC Commissioner Bart Chilton will continue to reassure us that nothing is amiss…and the evidence provided by the weekly Commitment of Traders Report is just a figment of our collective imaginations.JPMorgan Chase is the ringleader, of course…but I’m also getting the impression that Canada’s own Scotiabank/Scotia Mocatta is a major player in this short-side price management scheme as well…along with a handful of others, including the raptors.With what’s been happening over in the gold vaults at the Bank of England these days…maybe Her Majesty will spill the beans. Maybe the pope will be next to go on the tour. Where are John Cleese and Michael Palin when you really need them? Too bad Monty Python’s Flying Circus got cancelled, as I’m sure that they would have had a field day with this story.I mentioned the COT Report just a few paragraphs back…and yesterday was the cut-off for the one that comes out on Friday. I certainly hope that all of yesterday’s price and volume action is reported to the CFTC in a timely manner. Since the cut-off was at the 1:30 p.m. close of Comex trading, I very much doubt that the volume associated with the absolute low of the day, which came after the Comex close, will be in it.Not much happened during the Far East trading day on their Wednesday…and now that London has been open a few hours, both gold and silver are trending a bit higher. Of course, that doesn’t mean much if you use yesterday’s New York price action as a template. Instead of hitting the precious metals during the thinly-traded Far East market like they’ve been doing for the past month or so, they smacked it hard in the most liquid market of all…New York…with no news associated with it. The dollar index actually fell as all this was going on.As I hit the ‘send’ button at 5:15 a.m. Eastern time, gold’s volume is sneaking up there…and silver’s volume is about average. The dollar index is down about 10 basis points.All eyes will be on the Comex when trading begins at 8:20 a.m. Eastern time. With JPMorgan Chase putting everyone on notice that they’re back in town, it’s a given that the price action in the precious metals for the balance of 2012 will not be smooth sailing.See you on Thursday. Aben Resources (TSX.V: ABN) is a Canadian gold and silver exploration company with a focus on developing properties in the Yukon and Northwest Territories. The Company owns a 100% interest in the 18,314 acre Justin Gold Project located in SE Yukon. A 2,020 metre diamond drill program was carried out in 2011 to test never before drilled zones. Aben made a significant new greenfields gold discovery when it intercepted 60m of 1.19 g/t Au in hole JN11009 at the POW Zone. Additionally, a new high grade silver-copper zone was discovered at the Kangas Zone with hole JN11003 returning 1.07m of 7320 g/t Ag (234 oz/ton) and 3.52% Cu. Aben carried out an aggressive exploration and drill program in 2012 to follow up on the initial discoveries. The first drill hole in 2012, JN12011, returned 46.4m of 1.49 g/t Au and extended the gold mineralization at the discovery zone 85 metres laterally. The Company has four other prospective Yukon and NWT projects in its portfolio along with a seasoned management and geological team. Aben’s chairman, Ron Netolitzky, is credited with exploration success on numerous properties including three Western Canadian gold and silver projects which became producing mines. Please visit our website to learn more about the company and request information.
When Paul Kugelman was a kid, he had no shortage of friends. But as he grew older and entered middle age, his social world narrowed.”It was a very lonely time. I did go to work and I did have interactions at work, and I cherished those,” he says. “But you know, at the end of the day it was just me.”Kugelman’s story isn’t unusual: researchers say it can be difficult for men to hold on to friendships as they age. And the problem may begin in adolescence.New York University psychology professor Niobe Way, who has spent decades interviewing adolescent boys, points to the cultural messages boys get early on.”These are human beings with unbelievable emotional and social capacity. And we as a culture just completely try to zip it out of them,” she says.This week on Hidden Brain, we look at what happens when half the population gets the message that needing others is a sign of weakness and that being vulnerable is unmanly.Resources:This episode refers to the Harvard Study of Adult Development, Niobe Way’s book, Deep Secrets, and research on suicide rates and social interaction.The Hidden Brain radio show is hosted by Shankar Vedantam and produced by Parth Shah, Jennifer Schmidt, Rhaina Cohen, and Matthew Schwartz. Our supervising producer is Tara Boyle. You can also follow us on Twitter @hiddenbrain. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Next Article March 24, 2016 The only list that measures privately-held company performance across multiple dimensions—not just revenue. –shares Add to Queue Image credit: Monica Dipres 2019 Entrepreneur 360 List 2 min read Apply Now » Starbucks Starbucks’ New Prepaid Card Lets Customers Earn Awards Anywhere Phil Wahba In the latest change to how it tries to cultivate customer loyalty, Starbucks will launch a new prepaid card by year-end that will let customers earn points on any purchase — even if it’s not at Starbucks.The coffee giant announced its Starbucks Rewards Prepaid Card from Chase at its annual shareholder meeting on Wednesday in Seattle, just one of many new initiatives it unveiled in the hopes of building on the momentum that saw sales hit a record $19.2 billion last year.The prepaid card will be available later this year and usable at any retail locations that accept Visa.“We were sitting around thinking, wouldn’t it be nice if we all had a payment card that would enable you to earn Starbucks stars for every dollar spent using that card?” Starbucks COO Kevin Johnson told investors. “Now if this card were accepted virtually anywhere, this could become your primary card for shopping, for travel, for online spending.”Starbucks last month announced a controversial overhaul of its loyalty program coming next month. Patrons are currently rewarded for the number of visits they make, but as of April 12, rewards, or “stars” in Starbucks parlance, will be earned as a function of how much is spent. The move upset customers who typically opt for basic items rather than Starbucks’ fancier, and pricier, goods.The company’s upcoming prepaid card echoes the Plenti program, launched last year and led by stores such as Macy’s and Rite Aid with American Express which is a multi-brand loyalty program.Starbucks said yesterday that its new loyalty program has not cost it any customers: 500,000 people have signed up for the rewards program since the changes were announced, bringing total U.S. active members to more than 12 million, and one executive claimed the pace of signups has even picked up. More details on how customers will win points with the upcoming prepaid card will be announced later this year.Other initiatives Starbucks announced at the meeting were the expansion of Teavana into China and a line of latte products for the single-serving K-cup pods, including its seasonal pumpkin spice drink. This story originally appeared on Fortune Magazine
ArivalChris TorresMarketing AdviceMarketing Technology NewsNews Previous ArticleSEMI Teams with Cornell University to Accelerate Technology Development Using Machine Learning and AINext ArticleHow Salesforce CRM Improves Your Sales Pipeline and About Salesforce DX VCS Chris Torres, of the Tourism Marketing Agency, has written ‘How to Turn your Online Lookers into Bookers’: the first ever marketing book dedicated to tour & activitiesChris Torres, founder and director of Scottish company the Tourism Marketing Agency, has recently written ‘How to Turn your Online Lookers into Bookers’: the first ever marketing book dedicated to helping tour and activity companies improve their website, their performance on Google, and their social media engagement. ‘Lookers into Bookers’ will be published on June 28th.There are countless books about marketing, but no one has previously taken the time, and initiative, to write one specifically for the tours and activities sector. Chris Torres worked in website design and marketing for almost two decades before specialising in tourism. His company, the Tourism Marketing Agency, works on marketing campaigns for brands based in Europe, Africa, Asia, Australia, North and South America.Marketing Technology News: Absolutdata Named Best Overall AI-Based Analytics Company in 2019 AI Breakthrough Awards Program Chris Torres Writes First Ever Marketing Advice Book for the Tours and Activities Industry PRNewswireJune 30, 2019, 8:00 amJune 28, 2019 ‘Lookers into Bookers‘ is already getting plenty of attention, with plenty of pre-orders on the crowdfunding campaign and a foreword from Douglas Quinby, the CEO of Arival, the biggest international tours and activities conference in the world.“Whether you are just starting on your digital marketing journey, or you are far along on your adventure, use Lookers into Bookers as a guide to strategy and prioritisation, as a hands-on practical resource.”Douglas Quinby, Co-founder and CEO of ArivalAs well as starting up the Tourism Marketing Agency, Chris also founded the Digital Tourism Show: a tourism-focused international marketing community with regular videos available on Facebook, YouTube, and as podcasts. The Digital Tourism Show has been offering free marketing advice for over two years; writing this book was the next logical step after putting so much time and effort into all of the Digital Tourism Show’s video guides and interviews.Marketing Technology News: Gigapaces Partners with Tableau to Accelerate Machine Learning and Data VisualizationBoth Chris and the team at TMA hope that ‘Lookers into Bookers’ helps tour operators around the globe to grow their brands and flourish online. The tours and activities sector is growing as more and more travellers seek authentic or exciting experiences.At 80k words, ‘Lookers into Bookers’ is not a glancing attempt to cover the subject; it provides all of the tools you need to market your tours and activities business successfully.Marketing Technology News: Verve Releases SDK 4.0 To Supercharge The Revenue-Generating Power Of In-App Inventory
CVS Demands Employees Offer Health Info Or Pay More For Coverage Chain drugstore CVS is offering employees a choice: Reveal health info, including their weight, or pay as much as $600 more per year for their health insurance.Los Angeles Times: Report: CVS Caremark Demands Workers Disclose Weight, Health InfoEmployees at one of the nation’s largest drugstore chains must disclose personal health information — including their weight — or pay a $600-a-year fine, according to a published report. CVS Caremark Corp. is requiring workers to reveal the information to their company’s insurance carrier or pay an extra $50 a month for health coverage, according to the Boston Herald (Hamilton, 3/20).Marketplace: CVS Forces Workers To Reveal Weight Or Pay UpHealth care premiums being what they are, companies are trying to bring down costs by encouraging workers to get healthier. Maybe they pick up part of employees’ gym membership tab. But the pharmacy chain CVS is planning a wellness program with a twist. CVS will require employees to disclose their weight and other health benchmarks — or pay $600 more for health insurance. The data-driven program has inflamed privacy advocates. It’s also an open question as to whether these programs can achieve their goals of making people healthier and saving money (Garrison, 3/21). In other news, walk-in clinics continue to pop up around the nation as an alternative to regular doctors –Reuters: Analysis: Private Equity Funds Rapid Growth Of Walk-In ClinicsWalk-in clinics are popping up in shopping malls and main streets across the United States and private equity is helping fund the expansion. At least a dozen private equity firms have in the last few years plowed millions of dollars into urgent care clinics, which have become popular with people who do not have regular doctors or who like the convenience of their extended hours of operation (Abrahamian, 3/21). This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
Source:https://www.utsouthwestern.edu/newsroom/articles/year-2018/forecasting-dementia.html Reviewed by Kate Anderton, B.Sc. (Editor)Dec 11 2018Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases.A new study from UT Southwestern shows that single toxic tau proteins that stick together and spread degeneration across the brains of dementia patients have different shapes. The folds of these molecules hold information that could help diagnose – and perhaps one day treat – neurodegeneration in its earliest stages.The finding comes from a team of scientists appointed this month to a newly created network of international collaborators focused on improving treatment of neurodegenerative disorders. Funded by the Chan Zuckerberg Initiative, the UT Southwestern group is tasked with using its recent discoveries of the tau protein to develop clinical diagnostic tools.”Our expanded understanding of the tau protein structure changes how we think about detecting and treating Alzheimer’s disease and related dementias,” said Dr. Marc Diamond, Director of UT Southwestern’s Center for Alzheimer’s and Neurodegenerative Diseases. “The next step is to translate this knowledge into simple clinical tests that doctors will use to diagnose and eventually stop the neurodegeneration process at its earliest stages.”Dr. Diamond’s new study expands on research published in July from his lab that documented a structural “genesis” of Alzheimer’s disease – the basis of how a healthy tau protein changes shape and is then capable of assembling with other tau molecules to kill brain cells.The latest study published in eLife shows that harmful single tau molecules take different shapes that each correlates to a distinct type of larger assembly that will form and self-replicate across the brain. Dr. Diamond’s lab already established in a 2016 study that the structure of larger tau assemblies determines which type of dementia will occur – which regions of the brain will be affected and how quickly the disease will spread. But it was unknown what specified these larger structures. The new research reveals how a single tau molecule that changes shape at the beginning of the disease process contains the information that determines the configuration of the larger, toxic assemblies. This finding suggests that characterization of the conformation of single tau molecules could predict what incipient disease is occurring – Alzheimer’s or other types of dementia.Related StoriesResearchers discover novel cancer-promoting molecular mechanismDementia patients hospitalized and involved in transitional care at higher ratesNew app created to help people reduce exposure to anticholinergic medicationsScientists made these discoveries by extracting tau protein from cultured cells and human brains, isolating them as single molecules and determining what types of pathological assemblies they would subsequently produce in cells and mice. They determined that contrary to prior ideas, a single tau molecule, rather than being without definable structure, in fact has multiple, stable structures that each determine what type of subsequent pathological assembly it will form.Dr. Diamond’s team is trying to translate these findings into clinical tests that examine a patient’s blood or spinal fluid to detect the first biological signs of the abnormal tau, before the symptoms of memory loss and cognitive decline become apparent. His lab is also working to develop treatments to stabilize shape-shifting tau molecules, prevent them from assembling, or promote their clearance from the brain.A diagnostic test will be especially important once effective treatments are established to treat various forms of dementia, he said.”It’s probably too late once the effects of neurodegeneration are manifest,” said Dr. Diamond, a leading dementia expert credited with determining that tau acts like a prion – an infectious protein that can self-replicate. “We need to be able to diagnose the process early and know the specific type of neurodegeneration that is occurring, because that is the best chance we have to intervene with a personalized treatment. This is very analogous to how we currently use tumor genotyping to best diagnose and treat cancer.”Dr. Diamond is leading a three-person team at UT Southwestern selected by the Chan Zuckerberg Initiative to join its new Neurodegeneration Challenge Network, which brings together experimental scientists from diverse research fields to understand the underlying causes of neurodegenerative disorders. The UT Southwestern group is among nine teams across the country receiving more than $1 million each to further their research.
When young neurons are exposed to a foreign drug, such as nicotine, they create a molecular “memory,” said first author Ben Romoli, PhD, a postdoctoral fellow in the Dulcis’ lab. By increasing the expression of nicotine receptors and the molecular marker Nurr1, a protein that is normally found only in dopaminergic neurons, these GABA- and Glutamate-expressing neurons acquire the “readiness” to switch to a dopaminergic program when properly motivated by nicotine in the adult.”We found that when the same animals are exposed to nicotine in adulthood, a fraction of these ‘primed’ glutamatergic neurons in the reward center begins to express genes required to produce dopamine. More dopamine in the system generates enhanced reward responses that lead to increased nicotine preference.”Dulcis said uncovering the molecular mechanism and the identity of the neuronal network involved is an important step toward a fuller comprehension of how a complex condition like addiction may work. Previous studies have already shown that maternal smoking and early postnatal exposure to nicotine are associated with altered children’s behaviors and an increased propensity for drug abuse in humans. This new research in mice helps elucidate the mechanisms of how and why. Neonatal nicotine exposure primes VTA neurons for a fate they normally would not have taken, making them more susceptible to the effects of nicotine when the animals are again exposed to nicotine later in life.”Davide Dulcis, PhD, associate professor in the Department of Psychiatry, UC San Diego School of Medicine Reviewed by James Ives, M.Psych. (Editor)May 22 2019Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, report researchers at University of California San Diego School of Medicine in a study published “in press” April 24, 2019 in Biological Psychiatry.A UC San Diego School of Medicine team of scientists, headed by senior author Davide Dulcis, PhD, associate professor in the Department of Psychiatry, with colleagues at Veterans Affairs San Diego Healthcare System and Michigan State University, found that exposure to nicotine in the first few weeks of life (through maternal lactation) induced a variety of long-term neurological changes in young mice.Specifically, it caused a form of neuroplasticity that resulted in increased numbers of modified neurons in the ventral tagmental area (VTA) of the brain following nicotine re-exposure as adults. These neurons displayed a different biochemistry than other neurons, including greater receptivity to nicotine and a greater likelihood of subsequent addictive behavior. Our pre-clinical work identified new cellular and molecular targets that may guide future clinical studies to refine treatment strategies. Because we found that this form of nicotine-induced neuroplasticity facilitates addiction to other addictive substances, such as ethanol in adults, uncovering the mechanism contributing to increased addiction susceptibility offers the rare opportunity to discover new ways to interfere with the mechanism of drug-mediated plasticity and prevent the negative consequences on reward-seeking behavior in the adult.”Davide Dulcis Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsRepurposing a heart drug could increase survival rate of children with ependymomaStudy provides new insight into longitudinal decline in brain network integrity associated with agingResearchers said the results are highly relevant to tobacco control programs because the neonatal nicotine effect observed in the study were induced by exposure through maternal lactation and current state and local policies do not regulate this particular type of nicotine intake.”We are planning to investigate whether early exposure to other commonly used drugs, such as alcohol or recently legalized marijuana or opioids, can induce similar adaptations of the reward center that affects drug preferences in adulthood,” said Dulcis. “It would be also interesting to determine whether this form of neurotransmitter plasticity is inducible or reversible at different stages of life when the brain is still extremely plastic and prone to drug addiction, like in adolescence.”The scientists are also investigating applications aimed at improving the behavioral performance of animal models for diseases associated with a loss of dopaminergic neurons, such as Parkinson’s disease.Source:University of California – San DiegoJournal reference:Dulcis, D. et al. (2019) Neonatal nicotine exposure primes midbrain neurons to a dopaminergic phenotype and increases adult drug consumption. Biological Psychiatry. doi.org/10.1016/j.biopsych.2019.04.019.
Reviewed by James Ives, M.Psych. (Editor)Jun 27 2019Men who want to improve their libido or build body mass may want to think twice before using testosterone-boosting supplements – also known as “T boosters” – as research shows these alternatives to traditional testosterone replacement therapy may not have ingredients to support their claims, according to Mary K. Samplaski, MD, assistant professor of clinical urology at the Keck School of Medicine of USC. Many supplements on the market merely contain vitamins and minerals, but don’t do anything to improve testosterone. Often, people can be vulnerable to the marketing component of these products, making it difficult to tease out what is myth and what is reality.”Mary K. Samplaski, MD, Keck School of Medicine of USC Testosterone is the primary male sex hormone and the reason why men produce sperm and have Adam’s apples. It’s also why men develop more “masculine” features like bulging muscles, a deep voice, broad shoulders and a hairy chest. After age 30, most men experience a gradual decline in testosterone, sometimes causing these features to diminish or new symptoms to occur, like erectile dysfunction. In an attempt to turn back the hands of time, some men will turn to T boosters.Using a structured review approach, Samplaski and a team of researchers explored the active ingredients and advertised claims of 50 T boosting supplements. Their findings were published as an original article in The World Journal of Men’s Health.Researchers performed a Google search with the search term “Testosterone Booster,” thus mimicking a typical internet research for someone looking to increase testosterone levels, and then selected the first 50 products that came up in their search. Then, the team reviewed published scientific literature on testosterone and the 109 components found in the supplements. Zinc, fenugreek extract and vitamin B6 were three of the most common components in the supplements.Related StoriesBridging the Gaps to Advance Research in the Cannabis IndustryAXT enhances cellular research product portfolio with solutions from StemBioSysSchwann cells capable of generating protective myelin over nerves finds researchThe team also compared the content for each supplement with the Food and Drug Administration’s (FDA) Recommended Daily Allowance (RDA) and the upper tolerable intake level (UL) as set by the Institute of Medicine of the National Academy of Science.Of the 150 supplements, researchers came across 16 general claims to benefit patients, including claims to “boost T or free T”, “build body lean mass or muscle mass”, or “increase sex drive or libido.”While 90% of the T booster supplements claimed to boost testosterone, researchers found that less than 25% of the supplements had data to support their claims. Many also contained high doses of vitamins and minerals, occasionally more than the tolerable limit.Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases, according to the FDA. As such, Samplaski would like to see more regulation around testosterone-boosting supplements to protect consumers. She also would like to explore disseminating handouts to her patients with more accurate information in the hopes that it encourages patients to seek a medical professional for low testosterone issues.While no one can escape the effects of aging, Samplaski says there is something men can do to address their concerns. “The safest and most effective way for men to boost low testosterone levels is to talk with a medical professional or a nutritionist.” Source:University of Southern California – Health SciencesJournal reference:Samplaski, M.K. et al. (2019) ‘Testosterone Boosting’ Supplements Composition and Claims Are not Supported by the Academic Literature. The World Journal of Mens Health. doi.org/10.5534/wjmh.190043.
There are turbulent, unexpected currents crackling through Jupiter’s atmosphere, producing brilliant auroras. Juno, the NASA probe that has orbited the gas giant since 2016, passes over Jupiter’s polar regions ever 53.5 days, collecting data on the magnetic forces that produce ultrabright auroras above the huge planet. In a new paper, published July 8 in the journal Nature Astronomy, researchers working with Juno’s data discovered that the electric currents passing through Jupiter’s magnetosphere — the region of its atmosphere richest with magnetic field lines — don’t act as expected. The probe found less direct current — current that constantly flows in one direction — than physicists predicted. It was only about 50 million amperes, an incredibly powerful current, but not as high as theoretical models of Jupiter’s magnetosphere suggested would be present. That finding suggests that “alternating current” — current that flickers back and forth — plays a much bigger role in producing Jupiter’s auroras than anyone realized, the researchers wrote. On Jupiter, as on Earth, auroras are a product of whirling currents in magnetic fields interacting with high-energy particles from the sun. [10 Places in the Solar System We’d Most Like to Visit]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65951-jupiter-currents-magnetosphere-tesla.html?jwsource=cl已复制直播00:0000:3500:35 “These observations, combined with other Juno spacecraft measurements, show that alternating currents play a much greater role in generating Jupiter’s aurora than the direct current system,” Joachim Saur, an author of the paper, said in a statement. On Earth, we typically think of alternating and direct currents (AC and DC) in terms of electronics. Famously, in the late 19th century, inventors Thomas Edison and Nikola Tesla disagreed sharply over which method should be used to deliver power to electrical devices. DC power doesn’t convert as easily between different voltages, according to the U.S. Department of Energy (DOE), so Tesla wanted to turn the more-easily convertible AC into the standard. Edison, guarding his DC-dependant patents, resisted the change and spread misinformation that AC was more dangerous, according to the DOE. Tesla won out in the end, and AC became the standard for U.S. power plants. However, according to the DOE, direct current has regained favor as more battery-powered devices have come to market. Your lights are probably running on AC power, but there’s a good chance the device you’re reading this on relies on DC. (That’s why your laptop requires an AC adapter.) In the space around Jupiter, the proportion of AC to DC isn’t determined by feuding pre-modern inventors, but by the behavior of ions in the planet’s atmosphere. Jupiter has powerful currents than Earth for several reasons, including its huge size, its fast rate of spin and the excess of charged particles (ions) pumped out from volcanoes on the moon Io. That such a large proportion of those currents are AC seems to be a result of turbulence in the planet’s magnetic fields, the researchers wrote. Turbulence in this sense refers to the disordered way in which the magnetic fields’ shape and directionality fluctuates. And that turbulence is producing different effects at each of Jupiter’s two poles. In the time Juno has orbited Jupiter, the planet’s north pole has experienced about half the current of the south pole, the researchers wrote. That seems to be a result of the much more complex arrangement of magnetic field lines in the north, which interrupts the flow of currents. In the south, they wrote, the magnetic field lines are “smoother.” The effects of those differences are visible in the two poles’ auroras, they noted. In the north, the auroras tend to be more widely dispersed, with a structure of “filaments and flares.” In the south, the auroras tend to be more structured, with a “bright arc” extending out from the main oval where auroras occur. This research on Jupiter’s powerful magnetic fields, the researchers wrote, could inform their understanding of Earth’s weaker magnetic field — humanity’s main protection against harsh solar particles. Some researchers already suspected turbulence produced a significant proportion of currents around our planet. This work seems to lend credence to that idea. 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COMMENTS RELATED SHARE SHARE EMAIL NCLT approves JNPT’s resolution plan to purchase Dighi Port for ₹853 crore SHARE COMMENT Published on Vijay Kalantri says he will write to Bank of Baroda to rescind the tag Businessman Vijay Kalantri, the latest to be declared a wilful defaulter by a lender as part of a government plan to purge the banking system of bad loans, says he has been wrongly labelled.“A wilful defaulter is someone who has the capacity to pay but does not pay, or has siphoned off funds; both the cases are not applicable to me,” Kalantri told BusinessLine.On June 2, Bank of Baroda issued a public notice labelling Vijay Kalantri, his son Vishal Kalantri and Dighi Port as wilful defaulters.Dighi Port was jointly promoted by Balaji Infra Projects and IL&FS through a concession awarded by the Maharashtra government. Vijay Kalantri is Chairman and Managing Director of Balaji Infra Projects as well as Dighi Port before it was taken to the National Company Law Tribunal (NCLT) for debt resolution under the bankruptcy law.Kalantri said he will be writing to Bank of Baroda seeking to overturn the labelling.“We have not siphoned off funds. There is a forensic report which says everything is correct, and the bank auditor was on board. So there is nothing which is there to label me a wilful defaulter,” he claimed.The corporate insolvency resolution process of Dighi Port is nearing completion. “The resolution process extinguishes the guarantees and rights of the promoters,” Kalantri claimed. Dighi Port did not owe money to Bank of Baroda, but the bank stepped in to issue the public notice after its merger with Dena Bank and Vijaya Bank which were part of the consortium that had lent money to the troubled private port. “Dighi Port faltered because the government did not give it road and railway connectivity as promised. If it had,, the port would not have come to this stage; we would have made money out of it and paid off everybody,” Kalantri said, adding that the actual loan was for ₹785 crore which ballooned to ₹3,074.51 crore due to overdue interest and penalty. “What is ₹785 crore loan — it’s not a big amount for such a big project where I have invested more than ₹1,000 crore of my personal money. The port project was started in 2004, and until 2009, I never took one rupee as loan,” he added. June 05, 2019 ₹853-crore JNPT-Dighi Port deal in trouble Vijay Kalantri – SHASHI ASHIWAL