Tottenham manager Mauricio Pochettino 1 Mauricio Pochettino has verbally agreed a new long-term contract with Tottenham.The Argentine announced the news at a press conference on Friday ahead of his side’s trip to Chelsea on Monday night.He revealed that the new and improved deal will tie him to the north London club until 2021.Pochettino told the assembled reporters: “We started to speak before, a few months ago, and today I think is a good moment to communicate we have reached the verbal agreement.“I am very happy. I wanted to stay for many reasons. Tottenham have unbelievable potential. We created after two years here a great group of players.“We have a very strong squad, young, with potential to be a top team. The staff and the supporters are unbelievable, there is massive potential, why not stay here?“We create a good atmosphere on the training ground and I think we can achieve big things in the future. I believe in this project and this club. I want to stay here.” Pochettino has won widespread praise for the job he has done at White Hart Lane since succeeding Tim Sherwood in May 2014.He has brought an exciting, attacking brand of football to Tottenham and has transformed them into Premier League title challengers.The 44-year-old has drawn admiring glances from rival clubs, including Manchester United, and recently expressed a desire to manage Paris Saint-Germain.But he has now put any speculation over his future to bed by agreeing a new deal with Spurs. The club are on the brink of Champions League qualification this season and still have an outside chance of winning the title, trailing Leicester by seven points with three games to go.
(Visited 178 times, 1 visits today)FacebookTwitterPinterestSave分享0 At least 80% of the human genome is functional, scientists now say, based on a genetic survey called ENCODE that may force reassessment of what a gene is.The big news in human genetics this week is the publication of results by the ENCODE (Encyclopedia of DNA Elements) consortium, “the most ambitious human genetics project to date,” and what it reveals about function in the human genome. When the human genome was first published, scientists were surprised that only about 3% of it coded for proteins. That was before they knew about all the coded information in the “epigenome,” which includes RNA transcripts that regulate the code. The new results show that at least 80% of the human genome is, in fact, functional, rendering the evolutionary notion of “junk DNA” (leftovers from our evolutionary past) incorrect. Evolutionists themselves are writing the “eulogy for junk DNA.”There is so much buzz about this story that came out in Nature this week, all we can do is list some of the more prominent headlines. References to Nature are from the 6 September 2012 issue, volume 489, no. 54. Popular reports in the news media are too numerous to list.Nature’s news feature “ENCODE: The Human Encyclopaedia” by Brendan Maher begins, “First they sequenced it. Now they have surveyed its hinterlands. But no one knows how much more information the human genome holds, or when to stop looking for it.“Evolution is mentioned in some of the Nature papers, but after notions of “evolutionarily conserved” and “evolutionary constraints” are removed (which refer to lack of evolution), what is left is mostly assumption rather than discovery. In Nature‘s summary article “Genomics: ENCODE Explained,” one mention of evolution was not particularly helpful to Darwinists: “Why evolution would maintain large amounts of ‘useless’ DNA had remained a mystery, and seemed wasteful,” Barroso wrote. “It turns out, however, that there are good reasons to keep this DNA.” Then Barroso listed some of the good things the non-coding DNA does. In the section “Evolution and the Code,” two of the authors stashed most of the understanding in the future: “many aspects of post-transcriptional regulation, which may also drive evolutionary changes, are yet to be fully explored.” The other three authors did not mention evolution.Nature looked back at a quote by Nobel laureate David Baltimore 11 years ago when the human genome was first published: “Unless the human genome contains a lot of genes that are opaque to our computers, it is clear that we do not gain our undoubted complexity over worms and plants by using many more genes. Understanding what does give us our complexity — our enormous behavioural repertoire, ability to produce conscious action, remarkable physical coordination (shared with other vertebrates), precisely tuned alterations in response to external variations of the environment, learning, memory … need I go on? — remains a challenge for the future.” Now, Peter Bork and Richard Copley state that the ENCODE data “may offer insight into function and regulation beyond the level of individual genes. The draft is also a starting point for studies of the three-dimensional packing of the genome into a cell’s nucleus. Such packing is likely to influence gene regulation … The human genome lies before us, ready for interpretation.”Nature posted a video by members of the ENCODE team explaining what their published results mean to human genetics. ENCODE Lead Coordinator Ewan Birney describes the hundreds of terabytes of raw data generated in the 5-year project involving hundreds of people. “There are probably things that we have no idea what they’re doing and yet they’re doing something important,” he says, hinting at potentially more than 80% function. “It’s very hard to get over the density of information,” he said. Genes can no longer be considered discreet sections of code. The data looks more like a jungle. There are “places in the genome we thought were silent and they’re teeming with life,” he said.A profile of Ewan Birney was written by Elisabeth Pennisi in the current view of Science (Sept 7, 337:6099, page 1167-1169, doi:10.1126/science.337.6099.1159). Birney is “a self-taught programmer turned bioinformatician” who brought hundreds of people together and worked very hard to bring knowledge of the human genome to this point.“Human Genome Is Much More than Just Genes,” Elizabeth Pennisi wrote for Science NOW. The project provided a kind of “Google Maps” for the genome, allowing studies of the epigenome (codes above the genetic code) and regulatory elements that might be implicated in disease.“ENCODE Project Writes Eulogy for Junk DNA” is another article by Elizabeth Pennisi in Science Sept 7, pp. 1159-1161. Sample quotes by scientists:“I don’t think anyone would have anticipated even close to the amount of sequence that ENCODE has uncovered that looks like it has functional importance,” says John A. Stamatoyannopoulos, an ENCODE researcher at the University of Washington, Seattle.These results are going “to change the way a lot of [genomics] concepts are written about and presented in textbooks,” Stamatoyannopoulos predicts.“It’s a treasure trove of information,” says Manolis Kellis, a computational biologist at Massachusetts Institute of Technology (MIT) in Cambridge who analyzed data from the project.“What we found is how beautifully complex the biology really is,” says Jason Lieb, an ENCODE researcher at the University of North Carolina, Chapel Hill.“Regulation is a 3D puzzle that has to be put together,” Gingeras says. “That’s what ENCODE is putting out on the table.”Alongside a beautiful artwork of the DNA double helix, New Scientist echoed the theme that “junk DNA” is obsolete. “The reams of ‘junk’ DNA that make up the majority of our genetic code appear to have a purpose after all, according to the results of a global research project.” Switches, for instance, have a purpose: “The switches also appear to be spread out over the genome, with some being located at a distance from the gene they are controlling,” reporter Jessica Hamzelou wrote. “Around 95 per cent of the genome appears to be very close to a switch, suggesting that almost all of our DNA may be doing something important.“On Science Daily: “Mapping a World Beyond Genes” commented on the epigenome so central to the ENCODE project: “The term ‘epigenome‘ refers to a layer of chemical information on top of the genetic code, which helps determine when and where (and in what types of cells) genes will be active. This layer of information includes a suite of chemical changes that appear across the genetic landscape of every cell, and can differ dramatically between cell types.”“Yale Team Finds Order Amidst the Chaos Within the Human Genome,” announces another article on Science Daily. After describing the hierarchical information structure of the epigenome, likening it to management levels in a company (but with less “middle management” bottlenecks), this article looked for evidence for evolution in pseudogenes, calling them ” stretches of fossil DNA, evolutionary remnants of an active biological past.” These pseudogenes, though, are not dead: “However, the Yale team shows many of them are resurrected to produce non-coding RNAs, which scientists now know are crucial to the activation and silencing of protein-coding genes throughout the genome.” Remarkably, one of the Yale team members said this proves evolution is smartly economical: “This is another example of nature not wasting resources, a story we see repeated time and time again throughout the 3 billion letters of our genome.”Another article on Science Daily seems to dilute the evolutionary claim, though, claiming that ENCODE is a forward-looking project casting off obsolete evolutionary notions: “Fast Forward for Biomedical Research: Massive DNA Encyclopedia Scraps the Junk.” It includes another quote by Birney: “Our genome is simply alive with switches: millions of places that determine whether a gene is switched on or off.”Science Daily also printed a press release from the American Society for Biochemistry and Molecular Biology titled, “Major Advances in Understanding the Regulation and Organization of the Human Genome.” This article stressed how ENCODE is filling the “knowledge gap” that the notion of “junk DNA” explained away.“Biochemical Functions for Most of Human Genome Identified: New Map Finds Genetic Regulatory Elements Account for 80 Percent of Our DNA” is the title of another article on Science Daily. This one also mentioned evolution, but only briefly, referring to percentages of genes conserved across mammals. Some of these “newly evolved regulatory regions,” however, work to “encode regulators that activate other genes.”In a similar vein, another Science Daily article announced, “Millions of DNA Switches That Power Human Genome’s Operating System Are Discovered.” This article discussed not only the computers the scientists used, but how DNA has its own computer-like operating system.“Human Genome Far More Active Than Thought: GENCODE Consortium Discovers Far More Genes Than Previously Thought” announced another article on Science Daily. What is GENCODE? The article explained, “The GENCODE Consortium is part of the ENCODE Project that, today, publishes 30 research papers describing findings from their nearly decade-long effort to describe comprehensively all the active regions of our human genome.” The GENCODE team is looking for more genes and finding them. In addition, they found 11,000 “pseudogenes” and found “There is some emerging evidence that many of these genes, too, might have some biological activity.” This hints that pseudogenes may be elevated from evolutionary junk as more is learned about them.Of interest to philosophers of science is whether the ENCODE results will leave the notion of a “gene” intact. Another article on Science Daily is headlined, “In Massive Genome Analysis ENCODE Data Suggests ‘Gene’ Redefinition.” For one thing, the “junk DNA” advocates were wrong: “Far from being padding, many of these RNA messages appeared to be functional.” Even more important. genes are sometimes not distinct loci: “The additional knowledge that parts of one gene or functional RNA can reside within another were surprising, and suggested a picture of the architecture of our genome that was much more complex than previously thought.” Functions for the remaining 20% of DNA left undefined by ENCODE may be found in the differential gene expression within body tissues, because “a large percent of non-protein-coding RNAs are localized within cells in a manner consistent with their having functional roles.” And even though some RNAs are not associated with genes, they are increasingly viewed as something greater: a “giant, complex switchboard, controlling a network of many events in the cell by regulating the processes of replication, transcription and translation.” With these new realizations, one team member commented, “New definitions of a gene are needed.”According to an article in Science Daily, “The full ENCODE Consortium data sets can be freely accessed through the ENCODE project portal as well as at the University of California at Santa Cruz genome browser, the National Center for Biotechnology Information, and the European Bioinformatics Institute. Topic threads that run through several different papers can be explored via the ENCODE microsite page at Nature.com/encode.”The Wall Street Journal provides a sample of coverage from a media site not devoted to science per se: “‘Junk DNA’ debunked” is the headline. “The discovery ‘is like a huge set of floodlights being switched on’ to illuminate the darkest reaches of the genetic code, said Ewan Birney of the European Bioinformatics Institute in the U.K., lead analysis coordinator for the Encode results.” Stamatoyannopoulos commented, “We created a dictionary of the genome’s programming language.” Noting that humans have about 30 times as much ‘junk DNA’ (regulatory elements, actually) as other other species, the WSJ said, “The unexpected level of activity seen in the genomic hinterlands may also help explain what makes us human.” With 30+ papers on the ENCODE project in print and more coming, “The flood of scientific data is likely to keep researchers busy for a long time.”In contrast to all the above articles celebrating information and function in non-coding DNA, New Scientist posted a hold-out article advocating, “Don’t junk the ‘junk DNA’ just yet.” Is there still “function” in that vanishing term? “The ENCODE project has revealed that 80 per cent of our genome does something, but doing something is not the same as doing something useful,” the article points out: “there are still very good reasons for thinking that most of our DNA is far from essential.” The statement confuses “essential” with “adaptive” and begs the question whether something useful must be essential. A second hand is useful but not essential or else amputees would never have children. The short article was not specific and did not refer to evolution. “ENCODE is an epic project that will undoubtedly lead to many advances, but it is premature to leap to grand conclusions,” the article warned. “Just as the much anticipated human genome project revealed more than a decade ago, ENCODE tells us we still have an enormous amount to learn from the book of life.”Intelligent Design advocates are, meanwhile, gloating over the demise of “junk DNA” and pointing to the exceptional complexity ENCODE has revealed. Casey Luskin at Evolution News & Views whipped out “Junk No More: ENCODE Project Nature Paper Finds ‘Biochemical Functions for 80% of the Genome’” on the day of Nature‘s announcement. Robert Crowther reminded readers of Evolution News & Views that “Jonathan Wells Got It Right In The Myth of Junk DNA,” published by the Discovery Institute. “In 2010 in The Myth of Junk DNA, biologist Jonathan Wells exposed the false claim that ‘junk DNA’ provides decisive evidence for Darwin’s theory,” he said. “Now he has been vindicated by the leading scientific publications in the world.”Evolutionists are desperately struggling to hang onto their theory in the floodlights revealing layers of complexity far beyond anything Darwin could have conceived. Blobs of protoplasm, ha! How about operating systems, switchboards, and hierarchical management structures? It’s over, Darwinists. You messed up on vestigial organs, the fossil record and now junk DNA. Please step aside and let the science of the information age take care of what the evidence demands.
Three Anchor Bay’s bathing area is visiblein the bottom right of this scene ofMouille Point and Cape Town stadium.(Image: Cape Town Partnership) The three proposed pilot sites areshown in this Google Maps image.See a bigger version.(Images: City of Cape Town)MEDIA CONTACTS • Councillor Brett HerronMayoral committee member+27 21 400 1298Emily van RijswijckThe City of Cape Town has launched a year-long pilot project to improve the quality of storm water running into the sea at three of its popular bathing areas.According to the municipality, this is the first time that this kind of initiative, involving end-of-pipe treatment, will be undertaken in South Africa.If the project is successful it will be taken to other beaches along the city’s coastline.Two storm water outlet sites at Three Anchor Bay and one at Rocklands, in adjacent Sea Point, all within 10 minutes of the city centre, are earmarked for the pilot project, with infrastructure construction already under way.The sites were chosen because of their proximity to the city’s management offices as this minimises costs.A different treatment method will be used at each of the three sites to test the environmental impact and cost effectiveness as well as their efficacy under local conditions.At Three Anchor Bay North the low flow of water will be diverted to the city’s sewer system; conventional chlorine disinfection will be introduced at Three Anchor Bay South; and an ultraviolet disinfection process will be used at Rocklands.“The outcomes of the monitoring report will determine whether it is viable for the city to roll out interventions similar to the three pilots at other non-compliant bathing beaches, but on a much bigger scale,” says Brett Herron, mayoral committee member for Cape Town.Three Anchor Bay is wedged between Mouille Point and Sea Point on the Atlantic seaboard, considered to be one of Cape Town’s prime property locations.Along this beautiful stretch of beachfront lie the glamorous, sought-after areas of Clifton, Camps Bay, Fresnaye and Llandudno, each with its own character. Some have spectacular swimming beaches, and all share the magnificent Table Mountain and Twelve Apostles range as backdrop.Non-compliantPreliminary tests done by consulting engineers Jeffares and Green at strategic outlet areas in Sea Point and Mouille Point revealed that the quality of the storm water did not comply with the Department of Water Affairs’ regulations.The study also found that stormwater runoff was one of the major contributors to pollution of sea water in Cape Town, especially during low water-flow periods, says Herron.It is estimated that the construction process will take about five months, after which the assessment will start in earnest.A building being constructed at Rocklands will house the ultraviolet (UV) disinfection equipment. This technique makes use of UV light to penetrate bacterial cell walls, which, in turn, disrupts the reproduction process of the microbes.The method is considered to be simple and easy to install and maintain. Unlike the chlorine treatment, it leaves the water with no chemical taste or smell and is therefore more environment-friendly.For the chlorine disinfection method underground tanks will be installed at Three Anchor Bay South, while at the Three Anchor Bay North site low-flow diversion infrastructure will divert storm water via an underground system.“Since these are pilot projects, monitoring is essential, especially in the case of the chlorination treatment, to see if it is viable to continue with chlorination disinfection,” says Herron.The effect of chlorine on marine wildlife has not been established, but it is of concern to the municipality and will be closely monitored by an independent marine biologist.Feedback received from the public during the environmental impact assessment and public participation process had been “very positive”, says Herron.
Vice President Venkaiah Naidu on Saturday lambasted U.S. State department’s proposal to set up special fund to promote religious harmony and end discrimination in India.“American Senate has set up some fund for bringing harmony in India. I want to tell them that let them take care of what is happening in America, what is happening in their universities and what is happening in their restaurants. They should focus on them and spend money for them to reform their people,” Mr. Naidu said while addressing 13th convocation of city-based KIIT University here.According to reports, US State Department had announced a grant of $493,827 for reducing religiously-motivated violence and discrimination in India.“Our country is great. We have a huge population. There may be some incidents here and there. And the society has already understood the reality. We have to work together to see that these tendencies are curbed. There are isolated incidents and actions have been taken,” said Mr. Naidu.“But we cannot accept the view that somebody else is trying to teach and preach us. We should liberate us from prejudices, hatred and intolerance. Education should make us broad-minded, humble, patient and reasoned,” he pointed out. Mr. Naidu further said, “we don’t need any war. India has great history. We have never attacked any country in the world. But other small countries have attacked us. They ruled, ruined, looted and cheated us also. Why? Because we lost unity and forgot our culture. We have to remember the lesson. Others need not teach us lessons.”“You are inheritor of a great culture. I have told you the ancient culture that valued learning and knowledge and the culture that emphasised inclusion, truth and welfares of all. Adopt good practices and do not neglect welfare of suppressed and depressed people,” the Vice President observed speaking to students. “Our forefathers have said that Manav Seva hi Madhav Seva (Service to mankind is service to God). This is our philosophy and culture. This is our heritage.”According to KIIT University, 4,820 students received degrees during 13th Annual Convocation of KIIT University. Nobel Laureate Professor Harald zur Hausen, Padma Vibhushan Raghunath Mohapatra, Chairman Emeritus of Simplex Infrastructure Private Limited, Bithal Das Mundhra, and Chairman of Bharatia Charitable Trust, Kishanlal Agarwal were conferred with Honoris Causa Degree.
View comments PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss “I’m very happy we were able to bounce back in this game after suffering a very painful loss to Phoenix,” said Meralco coach Norman Black.“A lot of guys I felt really stepped up and helped us tonight led by Trevis, who made a lot of good outside shots for us and helped us open up [Blackwater’s] defense,” he added.Jackson, who played Division I basketball in the US NCAA, knocked in the triple that gave the Bolts the lead for good, 81-78, 5:18 left in the match.Cliff Hodge and Nico Salva then kept Meralco in front to preserve the early efforts of Mike Tolomia and Ranidel de Ocampo.Meralco got huge production from its bench, which outscored Blackwater’s reserves, 47-27, with six Bolts providing double-digit production.ADVERTISEMENT Don’t miss out on the latest news and information. Victolero ends Austria reign as Press corps’ top coach “That’s what we really envisioned going into this year when I drafted Trevis,” said Black. “I thought with him along with Baser (Amer) and Chris (Newsome), we’d spread the wealth and move the basketball around to get good shots and run a little bit, which we haven’t done in the past. “Blackwater managed to dump Meralco in a 12-point hole in the first half, but could not sustain that performance and dropped s second straight game.In the nightcap, Matthew Wright fired 23 points and had a key tip-in as Phoenix outlasted TNT in overtime, 93-84.Wright’s rescue of a missed Calvin Abueva drive helped the Fuel Masters zoom to the early lead with a 2-0 record while dropping the KaTropa to 0-2.Sports Related Videospowered by AdSparcRead Next LOOK: Joyce Pring goes public with engagement to Juancho Triviño Is Luis Manzano planning to propose to Jessy Mendiola? MOST READ Private companies step in to help SEA Games hosting Photo by Tristan Tamayo/INQUIRER.netANTIPOLO CITY—Trevis Jackson hardly needed to look for motivation as his Meralco Bolts took the floor against the Blackwater Elite Saturday at Ynares Center here.His fellow rookies, Robert Bolick of NorthPort and CJ Perez of Columbian, provided that for him when they came up with 26 points each in their debuts—both victories.ADVERTISEMENT “Those are awesome guys,” Jackson said. “I watched their games and I was excited. I feel like that excitement transferred over to me [and] I just told myself, ‘you gotta do it, you gotta give people something.’”He did just that.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsJackson came off the bench to provide a much-needed boost for Meralco in a 99-94 victory over Blackwater that allowed the Bolts to even their record after an opening-day loss to Phoenix.The surprise fifth pick of the PBA Draft, Jackson scattered 19 points and a pair of assists to lead the Bolts. SEA Games: Biñan football stadium stands out in preparedness, completion SEA Games hosting troubles anger Duterte TS Kammuri to enter PAR possibly a day after SEA Games opening LOOK: Joyce Pring goes public with engagement to Juancho Triviño SEA Games: Biñan football stadium stands out in preparedness, completion LATEST STORIES