first_imgThe body of 69-year-old farmer George Dove of La Bagatelle, Leguan was discovered on Saturday at about 06:45h stuck between rocks in the estuary of the Essequibo River in the vicinity of La Bagatelle, Leguan.When Dove’s body was retrieved, there were abrasions on its head and on the left side, suspected to have occurred while the body was washed up between the rocks.According to Police reports, Dove left home at about 10:00h on November 20 for his farm at Parika Backdam, where he would normally spend two to three weeks before returning home.On Friday, however, at 18:30h, a woman saw the pensioner lying on the Leguan wharf apparently under the influence of alcohol. The woman offered to take him home, since they are from the same community, but he refused the offer.His body was subsequently found the following morning.Guyana Times was told that the late George Dove had been in the habit of regularly consuming alcohol and falling into trenches.last_img read more

first_imgCurry then busts out into some signature Chris Brown moves and sings a few bars of “Run It!” Click here if viewing from a mobile device.Recently unearthed on the Internet is a hilarious video of Golden State Warriors star Stephen Curry having a playful time with a DoorDash food deliverer.After greeting his delivery person, Steph answers a question on why he looks familiar: “I’m Chris Brown, I used to sing from time to time.” Nevermind that Steph will not be winning any MVP …last_img read more

first_img(Visited 178 times, 1 visits today)FacebookTwitterPinterestSave分享0 At least 80% of the human genome is functional, scientists now say, based on a genetic survey called ENCODE that may force reassessment of what a gene is.The big news in human genetics this week is the publication of results by the ENCODE (Encyclopedia of DNA Elements) consortium, “the most ambitious human genetics project to date,” and what it reveals about function in the human genome.  When the human genome was first published, scientists were surprised that only about 3% of it coded for proteins.  That was before they knew about all the coded information in the “epigenome,” which includes RNA transcripts that regulate the code.  The new results show that at least 80% of the human genome is, in fact, functional, rendering the evolutionary notion of “junk DNA” (leftovers from our evolutionary past) incorrect.  Evolutionists themselves are writing the “eulogy for junk DNA.”There is so much buzz about this story that came out in Nature this week, all we can do is list some of the more prominent headlines.  References to Nature are from the 6 September 2012 issue, volume 489, no. 54.  Popular reports in the news media are too numerous to list.Nature’s news feature “ENCODE: The Human Encyclopaedia” by Brendan Maher begins, “First they sequenced it. Now they have surveyed its hinterlands. But no one knows how much more information the human genome holds, or when to stop looking for it.“Evolution is mentioned in some of the Nature papers, but after notions of “evolutionarily conserved” and “evolutionary constraints” are removed (which refer to lack of evolution), what is left is mostly assumption rather than discovery.  In Nature‘s summary article “Genomics: ENCODE Explained,” one mention of evolution was not particularly helpful to Darwinists: “Why evolution would maintain large amounts of ‘useless’ DNA had remained a mystery, and seemed wasteful,” Barroso wrote.  “It turns out, however, that there are good reasons to keep this DNA.”  Then Barroso listed some of the good things the non-coding DNA does.  In the section “Evolution and the Code,” two of the authors stashed most of the understanding in the future: “many aspects of post-transcriptional regulation, which may also drive evolutionary changes, are yet to be fully explored.”  The other three authors did not mention evolution.Nature looked back at a quote by Nobel laureate David Baltimore 11 years ago when the human genome was first published: “Unless the human genome contains a lot of genes that are opaque to our computers, it is clear that we do not gain our undoubted complexity over worms and plants by using many more genes. Understanding what does give us our complexity — our enormous behavioural repertoire, ability to produce conscious action, remarkable physical coordination (shared with other vertebrates), precisely tuned alterations in response to external variations of the environment, learning, memory … need I go on? — remains a challenge for the future.”   Now, Peter Bork and Richard Copley state that the ENCODE data “may offer insight into function and regulation beyond the level of individual genes. The draft is also a starting point for studies of the three-dimensional packing of the genome into a cell’s nucleus. Such packing is likely to influence gene regulation … The human genome lies before us, ready for interpretation.”Nature posted a video by members of the ENCODE team explaining what their published results mean to human genetics.  ENCODE Lead Coordinator Ewan Birney describes the hundreds of terabytes of raw data generated in the 5-year project involving hundreds of people.  “There are probably things that we have no idea what they’re doing and yet they’re doing something important,” he says, hinting at potentially more than 80% function.  “It’s very hard to get over the density of information,” he said.  Genes can no longer be considered discreet sections of code.  The data looks more like a jungle.  There are “places in the genome we thought were silent and they’re teeming with life,” he said.A profile of Ewan Birney was written by Elisabeth Pennisi in the current view of Science (Sept 7, 337:6099, page 1167-1169, doi:10.1126/science.337.6099.1159). Birney is “a self-taught programmer turned bioinformatician” who brought hundreds of people together and worked very hard to bring knowledge of the human genome to this point.“Human Genome Is Much More than Just Genes,” Elizabeth Pennisi wrote for Science  NOW.  The project provided a kind of “Google Maps” for the genome, allowing studies of the epigenome (codes above the genetic code) and regulatory elements that might be implicated in disease.“ENCODE Project Writes Eulogy for Junk DNA” is another article by Elizabeth Pennisi in Science Sept 7, pp. 1159-1161.  Sample quotes by scientists:“I don’t think anyone would have anticipated even close to the amount of sequence that ENCODE has uncovered that looks like it has functional importance,” says John A. Stamatoyannopoulos, an ENCODE researcher at the University of Washington, Seattle.These results are going “to change the way a lot of [genomics] concepts are written about and presented in textbooks,” Stamatoyannopoulos predicts.“It’s a treasure trove of information,” says Manolis Kellis, a computational biologist at Massachusetts Institute of Technology (MIT) in Cambridge who analyzed data from the project.“What we found is how beautifully complex the biology really is,” says Jason Lieb, an ENCODE researcher at the University of North Carolina, Chapel Hill.“Regulation is a 3D puzzle that has to be put together,” Gingeras says. “That’s what ENCODE is putting out on the table.”Alongside a beautiful artwork of the DNA double helix, New Scientist echoed the theme that “junk DNA” is obsolete.  “The reams of ‘junk’ DNA that make up the majority of our genetic code appear to have a purpose after all, according to the results of a global research project.”  Switches, for instance, have a purpose: “The switches also appear to be spread out over the genome, with some being located at a distance from the gene they are controlling,” reporter Jessica Hamzelou wrote.  “Around 95 per cent of the genome appears to be very close to a switch, suggesting that almost all of our DNA may be doing something important.“On Science Daily: “Mapping a World Beyond Genes” commented on the epigenome so central to the ENCODE project: “The term ‘epigenome‘ refers to a layer of chemical information on top of the genetic code, which helps determine when and where (and in what types of cells) genes will be active. This layer of information includes a suite of chemical changes that appear across the genetic landscape of every cell, and can differ dramatically between cell types.”“Yale Team Finds Order Amidst the Chaos Within the Human Genome,” announces another article on Science Daily.  After describing the hierarchical information structure of the epigenome, likening it to management levels in a company (but with less “middle management” bottlenecks), this article looked for evidence for evolution in pseudogenes, calling them ” stretches of fossil DNA, evolutionary remnants of an active biological past.”  These pseudogenes, though, are not dead: “However, the Yale team shows many of them are resurrected to produce non-coding RNAs, which scientists now know are crucial to the activation and silencing of protein-coding genes throughout the genome.”  Remarkably, one of the Yale team members said this proves evolution is smartly economical: “This is another example of nature not wasting resources, a story we see repeated time and time again throughout the 3 billion letters of our genome.”Another article on Science Daily seems to dilute the evolutionary claim, though, claiming that ENCODE is a forward-looking project casting off obsolete evolutionary notions: “Fast Forward for Biomedical Research: Massive DNA Encyclopedia Scraps the Junk.”  It includes another quote by Birney: “Our genome is simply alive with switches: millions of places that determine whether a gene is switched on or off.”Science Daily also printed a press release from the American Society for Biochemistry and Molecular Biology titled, “Major Advances in Understanding the Regulation and Organization of the Human Genome.”  This article stressed how ENCODE is filling the “knowledge gap” that the notion of “junk DNA” explained away.“Biochemical Functions for Most of Human Genome Identified: New Map Finds Genetic Regulatory Elements Account for 80 Percent of Our DNA” is the title of another article on Science Daily.  This one also mentioned evolution, but only briefly, referring to percentages of genes conserved across mammals.  Some of these “newly evolved regulatory regions,” however, work to “encode regulators that activate other genes.”In a similar vein, another Science Daily article announced, “Millions of DNA Switches That Power Human Genome’s Operating System Are Discovered.”  This article discussed not only the computers the scientists used, but how DNA has its own computer-like operating system.“Human Genome Far More Active Than Thought: GENCODE Consortium Discovers Far More Genes Than Previously Thought” announced another article on Science Daily.  What is GENCODE?  The article explained, “The GENCODE Consortium is part of the ENCODE Project that, today, publishes 30 research papers describing findings from their nearly decade-long effort to describe comprehensively all the active regions of our human genome.”  The GENCODE team is looking for more genes and finding them.  In addition, they found 11,000 “pseudogenes” and found “There is some emerging evidence that many of these genes, too, might have some biological activity.”  This hints that pseudogenes may be elevated from evolutionary junk as more is learned about them.Of interest to philosophers of science is whether the ENCODE results will leave the notion of a “gene” intact.  Another article on Science Daily is headlined, “In Massive Genome Analysis ENCODE Data Suggests ‘Gene’ Redefinition.”  For one thing, the “junk DNA” advocates were wrong: “Far from being padding, many of these RNA messages appeared to be functional.”  Even more important. genes are sometimes not distinct loci: “The additional knowledge that parts of one gene or functional RNA can reside within another were surprising, and suggested a picture of the architecture of our genome that was much more complex than previously thought.”  Functions for the remaining 20% of DNA left undefined by ENCODE may be found in the differential gene expression within body tissues, because “a large percent of non-protein-coding RNAs are localized within cells in a manner consistent with their having functional roles.”  And even though some RNAs are not associated with genes, they are increasingly viewed as something greater: a “giant, complex switchboard, controlling a network of many events in the cell by regulating the processes of replication, transcription and translation.”  With these new realizations, one team member commented, “New definitions of a gene are needed.”According to an article in Science Daily, “The full ENCODE Consortium data sets can be freely accessed through the ENCODE project portal as well as at the University of California at Santa Cruz genome browser, the National Center for Biotechnology Information, and the European Bioinformatics Institute. Topic threads that run through several different papers can be explored via the ENCODE microsite page at Nature.com/encode.”The Wall Street Journal provides a sample of coverage from a media site not devoted to science per se: “‘Junk DNA’ debunked” is the headline.  “The discovery ‘is like a huge set of floodlights being switched on’ to illuminate the darkest reaches of the genetic code, said Ewan Birney of the European Bioinformatics Institute in the U.K., lead analysis coordinator for the Encode results.” Stamatoyannopoulos commented, “We created a dictionary of the genome’s programming language.”  Noting that humans have about 30 times as much ‘junk DNA’ (regulatory elements, actually) as other other species, the WSJ said, “The unexpected level of activity seen in the genomic hinterlands may also help explain what makes us human.”  With 30+ papers on the ENCODE project in print and more coming, “The flood of scientific data is likely to keep researchers busy for a long time.”In contrast to all the above articles celebrating information and function in non-coding DNA, New Scientist posted a hold-out article advocating, “Don’t junk the ‘junk DNA’ just yet.”  Is there still “function” in that vanishing term?  “The ENCODE project has revealed that 80 per cent of our genome does something, but doing something is not the same as doing something useful,” the article points out: “there are still very good reasons for thinking that most of our DNA is far from essential.”  The statement confuses “essential” with “adaptive” and begs the question whether something useful must be essential.   A second hand is useful but not essential or else amputees would never have children.   The short article was not specific and did not refer to evolution.  “ENCODE is an epic project that will undoubtedly lead to many advances, but it is premature to leap to grand conclusions,” the article warned.  “Just as the much anticipated human genome project revealed more than a decade ago, ENCODE tells us we still have an enormous amount to learn from the book of life.”Intelligent Design advocates are, meanwhile, gloating over the demise of “junk DNA” and pointing to the exceptional complexity ENCODE has revealed.  Casey Luskin at Evolution News & Views whipped out “Junk No More: ENCODE Project Nature Paper Finds ‘Biochemical Functions for 80% of the Genome’” on the day of Nature‘s announcement.  Robert Crowther reminded readers of Evolution News & Views that “Jonathan Wells Got It Right In The Myth of Junk DNA,” published by the Discovery Institute.  “In 2010 in The Myth of Junk DNA, biologist Jonathan Wells exposed the false claim that ‘junk DNA’ provides decisive evidence for Darwin’s theory,” he said.  “Now he has been vindicated by the leading scientific publications in the world.”Evolutionists are desperately struggling to hang onto their theory in the floodlights revealing layers of complexity far beyond anything Darwin could have conceived.  Blobs of protoplasm, ha!  How about operating systems, switchboards, and hierarchical management structures?  It’s over, Darwinists.  You messed up on vestigial organs, the fossil record and now junk DNA.  Please step aside and let the science of the information age take care of what the evidence demands.last_img read more

first_imgSummaryReviewer Nathalie DuboisReview Date2018-06-22 12:17:35Reviewed Item Prettyland C498 – 32cm braun layered straight face-forming natural looked short daily WigRating 5.0 / 5  stars, based on  7  reviewsPrice£22.40 Fast postage and great product a++++. Really nice quality wig, very thick, exactly as in the photo. 🙂 i’m using it for trucy wright from ace attorney and it’s absolutely perfect for her. A decent product for the money. I do a lot of cosplay and my hair is “naturally” bright red. So finding a normal hair colour wig has been a search for me. I wear this wig to work reaguarly and it wasn’t seen any major signs of wear. For the price i find this amazing, its comfy and looks so natural. Best wig i have ever boughtReally nice quality wigbest wig i have boughtPrettyland C498 – 32cm braun layered straight face-forming natural looked short daily WigPrettyland C498 – braun layered straight face-forming natural looked short hair daily WigBeautiful short hair wig, in a natural brown for a great face shape and a great look.The hair is slightly layered and straight with inner swing. This makes the hair very beautiful.The wig has a natural look and cut, almost like natural hair and is perfect for everyday use.one adjustable Size, fits for a head circumference up to 60cm; with FREE Wig Cap Best wig i have ever bought. I am sick with cancer and i cant be happier. Looks so natural and nobody can tell i am sick. Hair is soft and doesnt tangle. This would be really nice for costumes or cosplay, but i wanted it for everyday use and it simply doesn’t look realistic for that. However, if you’re looking for a costume wig, this would be great. Forewarning, it is much thicker than it looks in the pictures. last_img read more

first_imgIt was a very disappointing performance by the Indians against New Zealand. One had thought that after giving the Dutch a run for their money in the first match, India would open their points tally against the Kiwis.It almost seemed like the team was unprepared and lacking in fight. The team looked disjointed and the strategy seemed lacking. There was a lot of gap between the forwards and the half-line.After taking an early lead, the Indians did not show much coordination or teamwork. Even when they went 1-3 down and time was running out, they allowed the New Zealanders to control the tempo. They easily regained possession due to wrong passing by the Indians. The Kiwis had thrashed India 5-1 at the recent Sultan Azlan Shah Cup.On the other hand, after our initial success with the penalty corner, we failed to make the other three count. Our drag flickers seemed to hit the ball at the rusher. There was no variation and it was very predictable for the Kiwis.Against the Dutch, India had a splendid second half when they went into all-out attack and made it 2-2. But there seemed no such urgency on Wednesday. Even when the team loses, one does not feel so bad if they fight till the bitter end.One saw the late match in which the Koreans gave a tough fight to the Germans, who were lucky to escape with a 1-0 win. That sort of defeat one does not mind.advertisementAfter conceding three goals in the first half, skipper Bharat Chetri was taken off at half-time and was replaced by PR Sreejesh.Probably, the team management wanted to avoid the possibility of Chetri letting in more goals. If the captain suffers a dent in confidence, it could have an adverse impact on the whole squad.As far as the forward line is concerned, the less said the better. SV Sunil tried to make forays into the opposition striking circle, but there was nobody to support him. Shivendra seemed lost.To make matters worse, indiscipline also marred India’s chances. Two key players, including Sardar Singh, had to spend time out after being shown yellow cards.This has been a bane of Indian hockey for long. I never got injured in my international career, but suffered several injuries in domestic hockey.Now, India face Germany next. They are the defending champions and are in a different league. India need to show more fight and if there is a miracle, we may get a positive result. We need to have an attacking mindset, but also be careful of defence.(The writer is a 1980 Moscow Olympics gold medallist)last_img read more

first_imgThe Lady Spikers lost to the Lady Maroons, 25-16, 26-24, 25-19, on Sunday in what was one of the defending champions’ sloppiest games so far when they had more errors, 37, than attack points, 28.With such an ugly loss, the Lady Spikers made a promise to themselves that they would bounce back and show that they’re still the reigning queens of the league.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsLa Salle easily dismantled National University, 25-20, 25-18, 25-10, on Wednesday at Filoil Flying V Center in a game that showed the pedigree of the 11-time champion.“We’re in La Salle and there are no cowards in La Salle,” said rookie star Jolina Dela Cruz in Filipino. “Coach [Ramil De Jesus] always reminds us of that and we just brought that spirit.” Cayetano: Senate, Drilon to be blamed for SEA Games mess MANILA, Philippines—De La Salle wasn’t going to let a three-set loss to University of the Philippines stop its momentum in the UAAP Season 81 women’s volleyball tournament.ADVERTISEMENT Dela Cruz is La Salle’s leading scorer with a total of 96 points after the game against the Lady Bulldogs but she wasn’t immune to De Jesus’ constant, and sometimes intense, lecturing.There were several times during timeouts that De Jesus would focus directly on Dela Cruz when he was conveying a message but the rookie was unfazed with the iconic coach’s intensity.“I just listened to him,” said Dela Cruz who had seven points against NU. “He always tells me to follow the game plan and follow his instructions so I won’t get lost on the floor.”ADVERTISEMENT Don’t miss out on the latest news and information. Colombia protesters vow new strike after talks hit snag MOST READ Panelo: Duterte ‘angry’ with SEA Games hosting hassles Google Philippines names new country director LATEST STORIEScenter_img View comments Goran Dragic, Luka Doncic put on a show for Slovenia Private companies step in to help SEA Games hosting Trump tells impeachment jokes at annual turkey pardon event Wintry storm delivers US travel woes before Thanksgiving Bloomberg: US would benefit from more, not fewer, immigrants Sports Related Videospowered by AdSparcRead Next PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krausslast_img read more